Gβγ subunit activation promotes dopamine efflux through the dopamine transporter
نویسندگان
چکیده
منابع مشابه
Amphetamine induces dopamine efflux through a dopamine transporter channel.
Drugs of abuse, including cocaine, amphetamine (AMPH), and heroin, elevate extracellular dopamine (DA) levels in the brain, thereby altering the activity/plasticity of reward circuits and precipitating addiction. The physiological release of DA occurs through the calcium-dependent fusion of a synaptic vesicle with the plasma membrane. Extracellular DA is cleared by uptake through the Na+/Cl- -d...
متن کاملDopamine Transporter Efflux in ADHD
Elevated dopamine efflux through the dopamine transporter may underlie some forms of attention-deficit hyperactivity disorder (ADHD), according to MazeiRobison et al. The authors identified a mutant form of dopamine transporter in two siblings with ADHD and expressed the mutant and wild-type forms in HEK-293T cells. Although expression levels and dopamine uptake were similar for mutant and wild...
متن کاملMOL #48447 1 Syntaxin1A Interaction with the Dopamine Transporter Promotes Amphetamine- Induced Dopamine Efflux
Department of Molecular Physiology & Biophysics, Center for Molecular Neuroscience, Kennedy Center for Research on Human Development, Vanderbilt University, 7124 MRBIII, 465 21 Ave S., Nashville, TN 37232 (FB, CD, EB, SED, BJL, RJC, KE, AG); Departments of Psychiatry and Pharmacology, Center for Molecular Recognition, College of Physicians and Surgeons, Columbia University, P&S 11-401, 630 W 16...
متن کاملSyntaxin 1A interaction with the dopamine transporter promotes amphetamine-induced dopamine efflux.
The soluble N-ethylmaleimide-sensitive factor attachment protein receptor protein syntaxin 1A (SYN1A) interacts with and regulates the function of transmembrane proteins, including ion channels and neurotransmitter transporters. Here, we define the first 33 amino acids of the N terminus of the dopamine (DA) transporter (DAT) as the site of direct interaction with SYN1A. Amphetamine (AMPH) incre...
متن کاملMitochondrial stress-induced dopamine efflux and neuronal damage by malonate involves the dopamine transporter.
Endogenous striatal dopamine (DA) overflow has been associated with neuropathological conditions resulting from ischemia, psychostimulants, and metabolic inhibition. Malonate, a reversible inhibitor of succinate dehydrogenase, models the effects of energy impairment in neurodegenerative disorders. We have previously reported that the striatal DA efflux and damage to DA nerve terminals resulting...
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ژورنال
عنوان ژورنال: Molecular Psychiatry
سال: 2017
ISSN: 1359-4184,1476-5578
DOI: 10.1038/mp.2017.176